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Folic Acid needs to be converted (methylated) in the intestines and liver to its active form 5-methyltetrahydrofolate (5-MeTHF) which is found in the blood and utilised by tissues. A very high percentage of people (60% in USA), have a genetic enzyme defect preventing them from converting Folic Acid to 5-Methyltetrahydrofolate, so 5 MTHF may be the only effective form of Folate supplementation for these people.
Methyltetrahydrofolate is the methyl group donor required for the conversion of homocysteine to methionine. Folate and vitamin B12 are also required for the synthesis of methionine and S-Adenosylmethionine ( SAMe). SAMe is the common methyl donor required for the maintenance of methylation patterns in DNA that determine gene expression and DNA conformation (Zingg and Jones, 1997).
5MTHF is also required for normal neurotransmitter production, such as serotonin, domamine, melatonin, adrenalin and noradrenalin. So is a good mood support and cardiovascular support.
5 MTHF is also important as the most bioavailable form of Folic Acid during pregnancy. It plays an important role in preventing chromosome breakage and hypomethylation of DNA. If folate deficiency occurs Uracil is incorporated into DNA instead of Thiamine(Eto and Krumdieck, 1986; Wagner, 1995; Fenech, 2001). This can lead to mutations.
1 capsule per day with food
Folic Acid is also known as Vitamin B9 and has a number of important physiological functions.
A proprietary blend of Vitamin B12 and Folic Acid.
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