Projuvenate (pot of 60 capsules)
A unique combination of the ingredients vitamin D3, vitamin K2 and astaxanthin.
Studies at Kings College London have linked both low and high blood levels of vitamin D in women with signs of cellular ageing, suggesting that normal blood levels prevent premature ageing. Further studies are proposed on the effect of vitamin D compounds on the expression and regulation of TAp63 and IGF-1 regulating signalling pathways (Reichrath, 2012).
Cellular ageing results from shortening of the telomeres on chromosomes. Telomeres are the DNA protein structures located at the end of chromosomes that shorten every time a cell replicates. The shorter the telomere becomes, the more it affects gene expression, resulting in cellular ageing. It has been proposed for some time that telomere length is a biomarker of ageing. Vitamin D3 supplementation has been associated with longer leukocyte telomere length (LTL) (Richards, et al., 2007).
Is known to play an important role (although the mechanism is unknown) in preventing premature ageing, due to its necessity for the functioning of an enzyme important in skin elasticity. In patients who suffer from pseudoxanthoma elasticum, a condition characterised by severe premature skin wrinkling, there is a dysfunction of this K2-dependent enzyme.
Is a powerful carotenoid from the algae Haematoccoccus pluvialis. Due to its molecular nature, astaxanthin acts as an extremely powerful antioxidant, absorbing the free radicals that cause skin ageing. In vitro studies at the Laboratory of Skin Pathology in Rome showed that astaxanthin reduced damage to cells exposed to UV radiation (Camera, et al., 2009).
A dermatological assessment gave women a 2 mg astaxanthin supplement, compared to a placebo group, which showed improvement in skin dryness, moisture content, roughness, elasticity and a decrease in wrinkles (Yamashita, 2006).