Vitamin E Mixed Tocotrienols
Vitamin E is actually composed of 8 naturally occurring isomers.
1) 4 x Tocopherols, known as alpha, beta, gamma and delta tocopherols
2) 4 x Tocotrienols, known as alpha, beta, gamma and delta tocotrienols
Many of the health benefits of these fractions can be attributed to the methyl groups attached to their molecules. Chemically tocotrienols have the same structure as tocopherols with 3 extra double bonds on their side chain.
Tocotrienols are found in rice, wheat, barley, rye and oats, but are particularly high in Red Palm Oil ( Elaeis guineensis) which can contain up to 800mg/kg.
Health benefits of Tocotrienols
Antioxidant – all 8 forms of vitamin E including all the tocotrienols act as antioxidants as they can donate a hydrogen atom to a free radical .Research showed that alpha tocotrienol was 40-60x more powerful than alpha tocopherol in an antioxidant capacity in the prevention of lipid peroxidation (Maniam et al. 2008).
It is also an effective antioxidant in the prevention of protein and lipid peroxidation after strenuous exercise for athletes, joggers and bodybuilders.Maintaining healthy cholesterol. Tocotrienol inhibits cholesterol production in the liver so decreasing total blood cholesterol ( Ajuluchkwu et al 2007) Tocotrienol suppresses hepatic HMG-CoA reductase activity that results in lowering of LDL cholesterol levels ( Qureshi et al 2002 ) Tocotrienols which are naturally occurring in palm oil have been shown to suppress/lower plasma cholesterol in humans and a combination of gamma tocotrienol and alpha tocopherol is found as a potential hypolipemic agent in hyperlipemic humans at atherogenic risk.
In a study published in 2011 in double blind placebo controlled clinical trials involving Tocomin SupraBio, patients receiving the SupraBio were reported to have a significant reduction ( 17%) of LDL cholesterol after supplementation.
Further randomized controlled clinical trials demonstrated that oral supplementation of Tocomin SupraBio for 2 months reduced arterial stiffness in healthy adults. Researchers at the University of Malaysia studied 36 volunteers randomised to receive either placebo, 50mg, 100mg, or 200mg Tocomin SupraBio self emulsifying tocotrienol complex for 2 months. All groups receiving the tocotrienol complex showed improvement in Augmentation index which is an indirect measure of arterial stiffness. The groups receiving 100mg and 200mg doses also showed improvement in Pulse Wave Velocity, also a measure of arterial stiffness (Rasool et al 2008).Reversal of Atherosclerosis / Arterial blockage. A 3 year double blind study conducted at the Jordan Heart Foundation, New Jersey Us, involving 50 patients with carotid stenosis (blockage of the carotid artery to the brain) showed that 6 months of supplementation with 240mg palm tocotrienol complex daily regressed carotid stenosis( decreased the amount of cholesterol plaque ) in 92% patients, compared to no improvement in the placebo group (Tomeo et al 1995 ) Studies conducted at the University of North Carolina confirmed the effect of tocotrienols in reversing arteriosclerosis, hence reducing the risks of cardiovascular diseases such as atherosclerosis and stroke. In this study, genetically.
modified mice, which were predestined to develop atherosclerosis when fed with diets high in triglycerides and cholesterol, was used. Not only did supplementation with palm tocotrienol complex lowered cholesterol and cholesterol ester by 66%, the size of the atherosclerotic lesions was 92% smaller (October 2000 , Journal of Nutrition).
Apolipoprotein B appears to be directly involved in the atherosclerotic process and recent studies have shown that gamma tocotrienol can reduce the atherogenic apoB plasma levels by 10-15%,( Hood RL 1996 ) by upregulation of LDL receptors in the liver which then facilitates clearance of LDL-apoB from the bloodstream (Wang Q et al 1998).
Lipoprotein A is also a risk factor for cardiovascular disease as it interferes with plasminogen activation and is associated with thrombosis. Tocotrienol has been shown to reduce plasma Lipoprotein A by 17% (Hood RL 1996)
Antithrombotic Properties. Thrombi occur when platelets stick together due to eicosanoids involved in platelet adhesion and aggregation. Studies involving tocotrienol complex demonstrated a reduction of the eicsanoid thromboxane B2 and suppression of platelet factor 4 (PF4) suggesting a protective effect on the vascular epithelium and platelet aggregation (Quershi et al 1995) Delta tocotrienol was significantly more potent than alpha or gamma tocotrienols in the inhibition of platelet aggregation.Neuroprotection – Mixed tocotrienol complex ( Tocomin SupraBio TM) has been shown to be effective in attenuating the progression of white matter lesions (WML). This is the largest ever study, the results of which were published in the American Heart Associations journal ,Stroke on April 3rd 2014 ( Gopalan et al 2014 ) White matter lesions are linked to increased stroke risk ( white matter is the area of the brain most often affected by stroke )and to the development of other neurodegenerative diseases such as Alzheimer's and Parkinson's disease. During this study, 121 volunteers age 35 and above with confirmed WMLs( by MRI) and increased cardiovascular risk factors, were randomised to receive 200mg or placebo twice daily. MRI imaging was taken at baseline, after 1 and after 2 years. After 2 years the mean WML volume of the placebo increased, whereas the supplemented group WML volume remained unchanged, the principle researcher, Prof Yuen concluding that supplementation with tocotrienol complex Tocomin SupraBio was effective at minimised the progresson of WMLs. It appears to be the alpha tocotrienol that is the most potent in supporting brain function in stroke related events
Anti Aging effects. Tocotrienols preferentially accumulate at the stratum corneum of the skin where they act as effective antioxidants, protecting against oxidative stress induced by UV light, so protecting against skin damage and skin aging ( Schaffer et al 2005 )
Hair Loss. Importantly studies have shown an association between oxidative stress and hair loss. Patients with hair loss generally exhibit lower levels of antioxidants in their scalp area as well as higher lipid peroxidation rate. Randomised, placebo controlled trials demonstrated that 8 month supplementation with tocotrienols showed a 34.5% increase in number of hairs, concluding that supplementation increases hair numbers, probably due to antioxidant activity of tocotrienols that helped to reduce lipid peroxidation and oxidative stress of the scalp (Beoy et al 2010).
In searching for the best quality, bioavailable, sustainable source of tocotrienols, Metabolics considered tocotrienols from rice, annatto seed and palm fatty acid distillate.
Tocotrienols from Annatto Seed were dismissed due to their solvent extraction, low level of gamma tocotrienol ( 10%) , absence of alpha and beta tocopherols and other important phytonutrients.
Tocotrienols from Rice were dismissed as the rice fatty acid distillate was a by product or scum from rice bran oil refining , had the lowest ratio of tocopherols to tocotrienols ( 50%;50% ), and negligible levels of alpha and beta tocotrienol.
Tocotrienol from Fatty Palm Acid distillate was also dismissed due to it being the by product or scum from palm oil refining, with deodorization at 270 degrees C, organic solvents used in their extraction containing only tocotrienols and tocopherol without other important nutrients.
Metabolics Tocomin Full Spectrum Tocotrienol Complex from Palm Fruits produced by Carotech Inc. Carotech is the only GMP certified tocotrienol producer in the market . It is also GMO free certified .Tocomin® is a registered trademark of Carotech Inc and protected by US Patent Nos. 5,157,132 and 7,544,822.
This is extracted by mild molecular distillation from Virgin Crude Palm Oil without the use of organic solvents. It also has the highest ratio of total tocotrienols to tocopherols ( typically 78%: 22%) This high ratio has been shown to be more effective at lowering serum cholesterol. This formulation contains the full spectrum tocotrienol complex, alpha, beta, gamma and delta tocotrienol in significant levels, the ratio and composition being exactly the same as found in palm fruits. This product has the highest gamma –tocotrienol ratio ( 45%-48%) , the gamma form of vitamin E being the form showing cardioprotection in research.
It also contains the other important phytonutrients such as phytosterols, squalene, mixed carotene and coQ10 that are naturally extracted along with the tocotrienols from palm fruits. Carotech tocomin full spectrum palm tocotrienol complex is presently being used in on going clinical trials on Neuroprotection and the US patented Bio-enhanced system guarantees increase in absorption by 200-300% making it the most bioavailable tocotrienol product in the market.
Bioavailability studies have been performed at the School of Pharmaceutical Sciences in Malaysia comparing the extent of absorption of tocotrienols compared to Tocomin SupraBio which showed that the latter was 3.3-3.5x more bioavailable. Metabolics have chosen Tocomin SupraBio to work with for its superior bioavailability.
Carotech’s Sustainability Policy
Palm oil is prodced in Peninsula Malaysia, Borneo and Indonesia.
All Carotechs palm oil comes only from Peninsula Malaysia, from plantations and growers that observe sustainable plantation practices, and are grown on existing crop land of more than 20 years. None of Carotechs palm oil is grown on cleared rain forest. Carotech has been a member of the Roundtable on Sustainable of Palm Oil (RSPO) since 2007.
Tocomin SupraBio® Tocotrienols are 100% Non-GMO, Kosher certified, and Halal certified, and are manufactured in accordance with the current Pharmaceutical Inspection Co-Operation Scheme (PIC/S) GMP Guides. No organic solvents are used in the extraction or processing of the tocotrienols.