{"title":"Brain Health","description":null,"products":[{"product_id":"omega-3","title":"Omega 3 EPA \u0026 DHA Capsules – Supports Heart, Brain \u0026 Eye Health","description":"\u003cp\u003eMetabolics Omega 3 oils are sourced from the flesh of the fish and not the livers. It is extracted from anchovy, sardine and mackerel caught off the coast of South America. It is a by-product of the Peruvian fishing industry, therefore making use of a product considered a waste product of another industry.\u003c\/p\u003e\n\u003cp\u003eHarvesting of fish for the General Law of Fishery regulates the fish oil industry and Marine Institute of Peru which constantly monitors Peruvian waters to ensure the presence of a constant biomass, thereby avoiding deprivation. The anchovy, Peru’s main fish species in the production of fish oil has maintained its population for the past 50 years due to a responsible catch policy. Every batch of oil is accompanied by a certificate of analysis which demonstrates that toxicity level of stated toxins such as pesticides and heavy metals is either non-existent or well below the permissible levels.\u003c\/p\u003e\n\u003cp\u003eOmega fats can oxidise and go rancid in the capsule leading to free radicals in the body. Taking rancid oil is dangerous because oxidized fats actually raise your risk of heart disease and blood clots, according to Rufus Turner, leading expert on oils at the University of Reading in the U.K. This product contains antioxidants in the form of mixed tocopherols to the capsules. These are naturally sourced and non GMO with a typical profile of, alpha tocopherol:13%, beta tocopherol 2%, gamma tocopheol 58%, delta tocopherol 27%. These are derived from vegetable oils by physical, not chemical extraction so leaving no chemical residues. \u003cstrong\u003eEvery batch of fish oil used in Metabolics Omega 3 has accompanying certification confirming any oxidation of the oil is either non existent or within the lower level of acceptable oxidation levels.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eStudies have shown that eating fish and certain fish oils can potentially expose you to a high degree of contamination with industrial pollutants and toxins like mercury, PCBs, heavy metals and radioactive poisons. \u003cstrong\u003eEvery batch of oil used in\u003c\/strong\u003e \u003cstrong\u003eMetabolics Omega 3 capsules is accompanied by a certificate of analysis which demonstrates that toxicity level of stated toxins such as pesticides and heavy metals is either non-existent or well below the permissible levels\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMost companies that provide Omega 3 oils, provide them in capsules made from bovine gelatine. Metabolics uses a premium high quality fish gelatine, providing uniformity of product throughout.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eWhy Choose Metabolics Omega 3 oils?\u003c\/h3\u003e\n\u003cp\u003eOmega 3 oils are one of a group of fats, which together with Omega 6 fats are Essential Fatty Acids (EFA). This means that they are essential for human health but cannot be made by the body. They have to be obtained from the diet.\u003c\/p\u003e\n\u003cp\u003eOmega 3 fatty acids are a group of 3 fats called ALA (Alpha Linoleic Acid - found in plant oils) EPA (Eicosapentaenoic acid) and DHA (Docosahexanoic acid) found in oily fish such as mackerel, herrings, sardines and salmon as well as algae and krill. The body is able to convert ALA to EPA and DHA, although it is not very efficient, making oily fish an important part of the diet.\u003c\/p\u003e\n\u003cp\u003eOmega 6 oils are found in plant oils and some animal fats.\u003c\/p\u003e\n\u003cp\u003eA ratio of 1:1 of Omega 3:6 oils is considered optimal. As Omega 6 is quite abundant in the Western diet, any deficiency is more commonly of Omega 3.\u003c\/p\u003e\n\u003cp\u003eOmega 3 (EPA and DHA) are needed for:\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eHeart health\u003c\/h3\u003e\n\u003cp\u003e\u003ca href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17047219\"\u003ehttp:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17047219\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eEPA and DHA (250mg daily intake) have been shown to reduce the risk of coronary death by 36% and total mortality by 17%. It has also been shown to prevent and treat atherosclerosis (hardening of the arteries) by slowing down the development of plaque and blood clots, which may clog up arteries. The beneficial effect for maintaining normal cardiac function is obtained from a daily intake if 250mg EPA and DHA.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eMaintaining normal blood fat levels.\u003c\/h3\u003e\n\u003cp\u003eEPA ,DHA and ALA contribute to normal blood cholesterol levels. This beneficial effect is obtained with a daily intake of 2gm DHA and a daily intake of 5gm combined EPA and DHA should not be exceeded.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eMaintaining normal blood pressure.\u003c\/h3\u003e\n\u003cp\u003eThis beneficial effect is obtained with intake of 3gm EPA and DHA, although a supplemental intake of 5gm DHA and EPA combined should not be exceeded\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eFor normal brain and eye development in the foetus and breastfed babies.\u003c\/h3\u003e\n\u003cp\u003ePregnant and lactating women can obtain a beneficial effect when doses of 200mg DHA are taken in addition to the recommended daily intake of Omega 3 fatty acids ( i.e 250mg DHA and EPA) Ref: Omega 3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. \u003ca href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18072818\"\u003eBy PM Kidd Published in Alternative Medicine review 2007 Sep;12 (3) : 207-27 \u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eFatty acids play a role in every single cell wall.\u003c\/h3\u003e\n\u003cp\u003eEvery cell wall is composed of phospholipids, which are arranged in two layers. A phospholipid is a fat joined onto a phosphate molecule.  The phosphate head of each layer faces outwards and attract water and the fat, hydrophobic or water hating tails face inwards.\u003c\/p\u003e\n\u003cp\u003eCell membranes are permanently under repair. EPA and DHA function via cell membranes in which they are anchored by phospholipid molecules.\u003c\/p\u003e","brand":"Metabolics","offers":[{"title":"90 Caps","offer_id":48071720403276,"sku":"OMEG390C","price":35.33,"currency_code":"GBP","in_stock":true},{"title":"250 Caps","offer_id":48071720436044,"sku":"OMEG3250C","price":64.26,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/6623\/0092\/files\/omega-3-epa-dha-capsules-supports-heart-brain-eye-health-5476703.png?v=1768344016"},{"product_id":"tyrosine-pot-of-90-capsules","title":"Tyrosine - 90 capsules","description":"\u003cp\u003eTyrosine is a significant amino acid that plays a role in:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThe synthesis of thyroid hormones T3 and T4. These are important for growth and metabolism.\u003c\/li\u003e\n\u003cli\u003eThe synthesis of catecholamines, for which it is a crucial starting ingredient. Catecholamines are hormones and neurotransmitters, and include dopamine, adrenaline (also known as\u003cstrong\u003e \u003c\/strong\u003eepinephrine) and noradrenaline (or norepinephrine ). They are released as a stress response, part of the fight-or-flight reaction, and help transfer signals between cells in the brain.\u003c\/li\u003e\n\u003cli\u003eThe synthesis of melanin, which colours the skin, hair and eyes.\n\u003cp\u003eSuggested dose: one capsule per day.\u003c\/p\u003e\n\u003cp\u003eBecause of tyrosines role in the creation of thyroid hormones, it should not be taken at the same time as thyroid medication unless under direct advice from a qualified healthcare professional.\u003c\/p\u003e\n\u003cp\u003eAdvice should also be sought before taking tyrosine if you have high blood pressure or are taking monoamine oxidase inhibitors (MAOIs).\u003c\/p\u003e\n\u003cp\u003eAn excess of tyrosine might cause skin, eye or brain problems. Tyrosine might trigger headaches in migraine sufferers.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis product \u003cstrong\u003eis\u003c\/strong\u003e suitable for vegetarians and vegans\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Metabolics","offers":[{"title":"Default Title","offer_id":48071728693580,"sku":"TYROS90C","price":24.39,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/6623\/0092\/files\/tyrosine-90-capsules-9022728.png?v=1771934539"},{"product_id":"dha-neurominstm-pot-of-60-soft-gel-capsules","title":"DHA - 60 soft gel capsules","description":"\u003ch3\u003eDHA (Docosahexanoic acid)\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003eDHA is an Omega 3 fatty acid (phospholipid) making up about a third of our brains. Omega 3 fatty acids are essential components of the cell membranes of all cells in the body. It is also abundant in the retina of our eyes and the conducting tissue of the heart. It is also found in the skin, sperm and testicles. DHA can be obtained directly from the flesh of cold-water fish along with EPA or the body can make small amounts from Alpha Linolenic Acid (ALA), found in flaxseed oil. Babies can directly receive DHA through breast milk.\u003c\/p\u003e\n\u003ch3\u003eFunctions of DHA\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eDHA contributes to the maintenance of normal brain function; the beneficial effect is obtained with a daily intake of 250 mg of DHA.\u003c\/li\u003e\n\u003cli\u003eDHA contributes to the maintenance of normal vision, the beneficial effect is obtained with a daily intake of 250mg of DHA.\u003c\/li\u003e\n\u003cli\u003eEPA and DHA contribute to the normal function of the heart - EPA and DHA contribute to the normal function of the heart - the beneficial effect is obtained with a daily intake of 250 mg of EPA and DHA.\u003cbr\u003e\n\u003ch3\u003eImportance during Pregnancy\u003c\/h3\u003e\n\u003cp\u003eAs there is such rapid growth and uptake of DHA during foetal and early neonatal life, intake of these polyunsaturated fatty acids (PUFA) is important before and during pregnancy.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003eDHA maternal intake contributes to the normal brain development of the foetus breastfed infants. This beneficial effect can be obtained by pregnant and lactating women with an intake of 200mg DHA, in addition to the RDA of 250mg DHA and EPA for Omega 3 fatty acids for adults.\u003c\/li\u003e\n\u003cli\u003eDHA contributes to the normal visual development of infants up to 12 months of age- this beneficial effect is obtained with a daily intake of 100mg DHA.\u003c\/li\u003e\n\u003cli\u003eDHA maternal intake contributes to the normal development of the eye of the foetus and breastfed infants- this beneficial effect is obtained with a daily intake of 200mg of DHA in addition to the 250mg RDA Omega 3 Fatty acids (EPA and DHA) for adults.\n\u003cp\u003eDHA is either found in Omega 3 oils, along with DHA or in vegetarian form manufactured from the algae Schizochytrium. This product is suitable for vegetarians.\u003cbr\u003e\u003cbr\u003eRecommended daily intake - 1 x 200mg capsule DHA.\u003c\/p\u003e\n\u003cp\u003eThis product is \u003cstrong\u003esuitable for vegetarians and vegans\u003cstrong\u003e.\u003c\/strong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Metabolics","offers":[{"title":"Default Title","offer_id":48071731642700,"sku":"DHA_60C","price":41.58,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/6623\/0092\/files\/dha-60-soft-gel-capsules-6692767.png?v=1771518686"},{"product_id":"choline-600-pot-of-60-capsules","title":"Choline - 60 capsules","description":"\u003ch3\u003eCholine Supplement\u003c\/h3\u003e\n\u003cp\u003eCholine is an essential water-soluble nutrient, and considered part of the B vitamin complex. The body makes choline in small amounts but it is essential to obtain enough to meet the body's needs through the diet or adequate supplementation. Choline is found predominantly as phosphatidylcholine in beef liver, wheat germ and eggs, so vegetarians and vegans may be at risk of deficiency.\u003c\/p\u003e\n\u003cp\u003eCholine is a very important, but little known, vitamin.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCholine contributes to normal homocysteine metabolism.\u003c\/strong\u003e Homocysteine is a naturally occurring amino acid in the blood which is produced when the body breaks down an amino acid called methionine. It should break down to cystathione which is then excreted out of the body. High levels of homocysteine can thicken and damage the walls of arteries. High homocysteine has been found in some people with autism. Choline is a precursor for the formation of betaine. Betaine acts as a methyl donor in the re-methylation of homocysteine in the liver by the enzyme betaine-homocysteine methyltransferase. Choline depleted diets tend to increase plasma concentrations of homocysteine. One human intervention study showed a significant decrease in plasma concentration of homocysteine following choline administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCholine contributes to normal lipid metabolism.\u003c\/strong\u003e Choline is a precursor of phospholipids and plays a role in the structural integrity and fluidity of cell membranes. The predominant phospholipid in the cell wall is phosphatidylcholine. Cells need these phospholipids constantly for normal function.\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eCholine contributes to the maintenance of normal liver function.\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003eCholine also plays a role in lipid and cholesterol transport and metabolism.\u003c\/li\u003e\n\u003cli\u003eDietary fat and cholesterol are transported to the liver by lipoproteins called chylomicrons. In the liver the fat and cholesterol are packaged into very low-density lipoproteins (VLDL) so that they can be transported through the blood to needy tissues. Phosphatidylcholine is needed as a component of VDLPs and fat can accumulate in the liver without enough phosphatidylcholine (fatty liver = hepatosteatosis). Choline deficiency is also associated with liver damage (elevated serum alanine aminotransferase activity). Studies where humans have developed fatty liver as a result of a choline deficient diet, have shown a complete reversal with the administration of sufficient dietary choline.\n\u003cp\u003eThis makes choline a vitally important nutrient not only in the adult but also in the developing foetus and child. For this reason Metabolics includes Choline in the \u003ca rel=\"noopener\" href=\"https:\/\/www.metabolics.com\/preconception-formula-pot-of-180-capsules.html\" target=\"_blank\"\u003ePreconception\u003c\/a\u003e and \u003ca rel=\"noopener\" href=\"https:\/\/www.metabolics.com\/antenatal-formula-pot-of-180-capsules.html\" target=\"_blank\"\u003eAntenatal\u003c\/a\u003e formulations.\u003c\/p\u003e\n\u003cp\u003eThere is no RDA or Upper Limit at present although the Linus Pauling Institute recommends 550mg\/day for men and 425mg women.\u003c\/p\u003e\n\u003cp\u003eEach 600mg capsule Metabolics Choline bitartrate supplies 240mg Choline, so recommended daily intake is 1 capsule a day with food.\u003c\/p\u003e\n\u003ch3\u003eQuality Assured:\u003c\/h3\u003e\n\u003cp style=\"height: 40px; vertical-align: middle;\"\u003e\u003cimg alt=\"GMP Supplements\" src=\"https:\/\/www.metabolics.com\/media\/wysiwyg\/metabolicsimages\/Siteimages\/GMP.png\" title=\"GMP Supplements\" style=\"width: 40px; height: 40px; vertical-align: middle;\"\u003e \u003ca rel=\"noopener\" href=\"https:\/\/www.metabolics.com\/blog\/how-are-your-supplements-made\/\" target=\"_blank\"\u003eMade to \u003cstrong\u003eGMP\u003c\/strong\u003e standards.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"height: 40px; vertical-align: middle;\"\u003e\u003cimg alt=\"Made in the UK\" src=\"https:\/\/www.metabolics.com\/media\/wysiwyg\/metabolicsimages\/Siteimages\/UKmade.png\" title=\"UK Made\" style=\"width: 40px; height: 40px; vertical-align: middle;\"\u003e \u003ca rel=\"noopener\" href=\"https:\/\/www.metabolics.com\/video-production-tour\" target=\"_blank\"\u003eMade in our \u003cstrong\u003eclean room facility\u003c\/strong\u003e, here in the \u003cstrong\u003eUK.\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"height: 40px; vertical-align: middle;\"\u003e\u003cimg alt=\"ISO accredited\" src=\"https:\/\/www.metabolics.com\/media\/wysiwyg\/metabolicsimages\/Siteimages\/ISO.png\" title=\"Tick\" style=\"width: 40px; height: 40px; vertical-align: middle;\"\u003e \u003ca rel=\"noopener\" href=\"https:\/\/www.metabolics.com\/metabolics-accreditations\" target=\"_blank\"\u003e\u003cstrong\u003eISO:9001\u003c\/strong\u003e and \u003cstrong\u003eISO:14001\u003c\/strong\u003e accredited.\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Metabolics","offers":[{"title":"Default Title","offer_id":48071772111180,"sku":"CHOL600C","price":21.55,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/6623\/0092\/files\/choline-60-capsules-4075510.png?v=1771934671"},{"product_id":"vitamin-b12-methylcobalamin-pot-of-90-capsules","title":"Vitamin B12 (Methylcobalamin) - 90 Capsules","description":"\u003ch3 class=\"MsoNormal\"\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eMetabolics Vitamin B12 (Methylcobalamin) \u003c\/span\u003e\u003c\/h3\u003e\n\u003ch3 class=\"MsoNormal\"\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eWhat Is Metabolics Vitamin B12 (Methylcobalamin)?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eVitamin B12 is one of the 13 essential vitamins needed by the human body to support life and health. It stands out among the vitamins as it cannot be obtained from plants or through sunlight. Instead, it is synthesised by bacteria in the gut of animals and absorbed in the small intestine.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eDietary sources of B12 include meat, fish, and dairy products, but even individuals with animal-based diets may struggle to absorb sufficient B12 due to the complex multi-step absorption pathway.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eVitamin B12 is first released from food in the stomach with the help of acid and enzymes. It binds to a carrier protein (haptocorrin) and is later freed in the small intestine. B12 then attaches to Intrinsic Factor, which helps it travel to the ileum for absorption into the bloodstream. Once absorbed, it is delivered to body tissues by Transcobalamin II. Without enough stomach acid, Intrinsic Factor, or healthy intestines, B12 absorption can be reduced.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eVitamin B12 deficiency can affect anyone at any age, but certain groups are at higher risk. These include vegans and vegetarians, adults over 60, individuals with eating disorders such as anorexia or bulimia, and those taking medications like antacids or diabetes treatments that interfere with B12 absorption. People with a history of alcoholism, anaemia, or gastrointestinal conditions such as Crohn’s disease and IBS are also more vulnerable. Autoimmune conditions like type 1 diabetes, Addison’s disease, and SLE can increase risk, as can a family history of pernicious anaemia. Women with infertility or recurrent miscarriage, as well as infants born to or breastfed by deficient mothers, should also be aware of their B12 status.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e\u003cstrong\u003eWhat is Methylcobalamin?\u003c\/strong\u003e\u003cbr\u003eMethylcobalamin is a bioactive, coenzyme form of vitamin B12. It consists of a cobalt ion (Co³\u003c\/span\u003e\u003cspan style=\"font-family: 'Cambria Math',serif; mso-bidi-font-family: 'Cambria Math';\"\u003e⁺\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e) held within a corrin ring structure, directly attached to a methyl group (-CH\u003c\/span\u003e\u003cspan style=\"font-family: 'Cambria Math',serif; mso-bidi-font-family: 'Cambria Math';\"\u003e₃\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e). As an active form, it does not require conversion in the body and is essential for homocysteine methylation and the maintenance of healthy nerve cells.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e\u003cstrong\u003eWhat Is Methylation and Why Is It Important?\u003c\/strong\u003e\u003cbr\u003eMethylation is a crucial biochemical process in which a methyl group (CH\u003c\/span\u003e\u003cspan style=\"font-family: 'Cambria Math',serif; mso-bidi-font-family: 'Cambria Math';\"\u003e₃\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e) is added to molecules within the body. It affects many essential functions, including gene expression, detoxification, neurotransmitter production, hormone regulation, and energy metabolism.\u003cbr\u003eVitamin B12 is critical to this process, as it helps convert homocysteine into methionine — a precursor to S-adenosylmethionine (SAMe), which supports emotional balance, detox pathways, and healthy cellular function. Because methylcobalamin is already in a methylated, active form, it can be directly used by the body. This is especially valuable for individuals with MTHFR gene variants, who may have difficulty generating sufficient methyl groups.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 class=\"MsoNormal\"\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eWhat Is Metabolics Vitamin B12 (Methylcobalamin) For?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eThis product offers high strength vitamin B12 in its active form, methylcobalamin, which is directly used by the body without the need for conversion.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 class=\"MsoNormal\"\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eKey Benefits of Vitamin B12\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Segoe UI Symbol',sans-serif; mso-bidi-font-family: 'Segoe UI Symbol';\"\u003e✔\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Contributes to Normal Energy-Yielding Metabolism\u003cbr\u003eVitamin B12 supports the conversion of food into energy by acting as a coenzyme in the breakdown of fatty acids and amino acids, helping sustain vitality throughout the day.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Segoe UI Symbol',sans-serif; mso-bidi-font-family: 'Segoe UI Symbol';\"\u003e✔\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Supports the Normal Function of the Nervous System\u003cbr\u003eEssential for the maintenance of the myelin sheath that protects nerve fibres, B12 ensures proper nerve conduction and coordination. Deficiency can lead to neurological symptoms such as numbness, tingling, and cognitive decline.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Segoe UI Symbol',sans-serif; mso-bidi-font-family: 'Segoe UI Symbol';\"\u003e✔\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Contributes to Normal Homocysteine Metabolism\u003cbr\u003eMethylcobalamin is involved in the conversion of homocysteine into methionine. This helps maintain cardiovascular health and reduce homocysteine levels, which are associated with heart disease risk.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Segoe UI Symbol',sans-serif; mso-bidi-font-family: 'Segoe UI Symbol';\"\u003e✔\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Supports Normal Psychological Function\u003cbr\u003eB12 contributes to the synthesis of neurotransmitters and supports brain function, memory, and emotional balance. Deficiency may manifest as irritability, low mood, or even cognitive impairment.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Segoe UI Symbol',sans-serif; mso-bidi-font-family: 'Segoe UI Symbol';\"\u003e✔\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Contributes to Normal Red Blood Cell Formation\u003cbr\u003eEssential for DNA synthesis, vitamin B12 supports the production of healthy red blood cells. A deficiency can lead to megaloblastic anaemia, characterised by fatigue and weakness.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Segoe UI Symbol',sans-serif; mso-bidi-font-family: 'Segoe UI Symbol';\"\u003e✔\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Supports the Normal Function of the Immune System\u003cbr\u003eBy promoting the integrity of DNA synthesis and cell division, B12 plays a role in supporting immune cell development and resilience.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Segoe UI Symbol',sans-serif; mso-bidi-font-family: 'Segoe UI Symbol';\"\u003e✔\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Has a Role in the Process of Cell Division\u003cbr\u003eB12 is crucial for cell replication, especially in tissues with high turnover, such as the lining of the gut and the production of immune and blood cells.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Segoe UI Symbol',sans-serif; mso-bidi-font-family: 'Segoe UI Symbol';\"\u003e✔\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Contributes to the Reduction of Tiredness and Fatigue\u003cbr\u003eBecause of its involvement in red blood cell formation and energy production, B12 can help reduce fatigue, particularly in individuals with low micronutrient status.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eSigns of Vitamin B12 Deficiency May Include:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e• Fatigue and low energy\u003cbr\u003e• Mood changes such as irritability, depression, or confusion\u003cbr\u003e• Numbness or tingling in extremities\u003cbr\u003e• Pale skin and breathlessness (linked to anaemia)\u003cbr\u003e• Digestive discomfort, bloating, constipation\u003cbr\u003e• Memory loss or neurological decline\u003cbr\u003e• Poor wound healing and susceptibility to infection\u003cbr\u003e• Vitiligo, premature greying, or skin changes\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 class=\"MsoNormal\"\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eWho Is Metabolics Vitamin B12 (Methylcobalamin) For?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eThis supplement is ideal for individuals who:\u003cbr\u003e\u003c\/span\u003e\u003cspan style=\"font-family: 'Segoe UI Symbol',sans-serif; mso-bidi-font-family: 'Segoe UI Symbol';\"\u003e✔\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Follow vegan or vegetarian diets\u003cbr\u003e\u003c\/span\u003e\u003cspan style=\"font-family: 'Segoe UI Symbol',sans-serif; mso-bidi-font-family: 'Segoe UI Symbol';\"\u003e✔\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Have increased nutritional demands due to lifestyle, age, or health status\u003cbr\u003e\u003c\/span\u003e\u003cspan style=\"font-family: 'Segoe UI Symbol',sans-serif; mso-bidi-font-family: 'Segoe UI Symbol';\"\u003e✔\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Show signs of deficiency such as fatigue, tingling, or mood disturbances\u003cbr\u003e\u003c\/span\u003e\u003cspan style=\"font-family: 'Segoe UI Symbol',sans-serif; mso-bidi-font-family: 'Segoe UI Symbol';\"\u003e✔\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Require a bioactive, high-quality, methylated form of B12\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 class=\"MsoNormal\"\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003eWhy Choose Metabolics Vitamin B12 (Methylcobalamin)?\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Segoe UI Emoji',sans-serif; mso-bidi-font-family: 'Segoe UI Emoji';\"\u003e🔹\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Scientifically Validated – Supported by UK \u0026amp; EFSA-authorised health claims\u003cbr\u003e\u003c\/span\u003e\u003cspan style=\"font-family: 'Segoe UI Emoji',sans-serif; mso-bidi-font-family: 'Segoe UI Emoji';\"\u003e🔹\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Bioavailable Active Form – Methylcobalamin is directly used by the body\u003cbr\u003e\u003c\/span\u003e\u003cspan style=\"font-family: 'Segoe UI Emoji',sans-serif; mso-bidi-font-family: 'Segoe UI Emoji';\"\u003e🔹\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Clean Formulation – Free from unnecessary additives\u003cbr\u003e\u003c\/span\u003e\u003cspan style=\"font-family: 'Segoe UI Emoji',sans-serif; mso-bidi-font-family: 'Segoe UI Emoji';\"\u003e🔹\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Third-Party Tested – Independently verified for quality and purity\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Segoe UI Emoji',sans-serif; mso-bidi-font-family: 'Segoe UI Emoji';\"\u003e✅\u003c\/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; mso-ascii-theme-font: minor-bidi; mso-hansi-theme-font: minor-bidi; mso-bidi-theme-font: minor-bidi;\"\u003e Order \u003cstrong\u003eMetabolics Vitamin B12 (Methylcobalamin) \u003c\/strong\u003eToday!\u003cbr\u003eSupport your energy, mental clarity, and neurological function with this high-quality supplement. Shop now and prioritise your health.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Metabolics","offers":[{"title":"Default Title","offer_id":48071772832076,"sku":"METHY90C","price":21.55,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/6623\/0092\/files\/vitamin-b12-methylcobalamin-90-capsules-7886132.png?v=1771516786"},{"product_id":"methyltetrahydrofolate-pot-of-60-capsules","title":"Methyltetrahydrofolate - 60 Capsules","description":"\u003ch3\u003eMethyltetrahydrofolate Capsules\u003c\/h3\u003e\n\u003cp\u003eFolic Acid needs to be converted (methylated) in the intestines and liver to its active form 5-methyltetrahydrofolate (5-MeTHF) which is found in the blood and utilised by tissues. A very high percentage of people (60% in USA), have a genetic enzyme defect preventing them from converting Folic Acid to 5-Methyltetrahydrofolate, so 5 MTHF may be the only effective form of Folate supplementation for these people.\n\u003c\/p\u003e\u003ch3\u003eWhy Use Metabolics Methyltetrahydrofolate?\u003c\/h3\u003e\n\u003cli\u003eFolate contributes to maternal tissue growth during pregnancy\n\u003c\/li\u003e\u003cli\u003eFolate contributes to normal amino acid synthesis\n\u003c\/li\u003e\u003cli\u003eFolate contributes to normal red blood formation\n\u003c\/li\u003e\u003cli\u003eFolate contributes to normal homocysteine metabolism\n\u003c\/li\u003e\u003cli\u003eFolate contributes to normal psychological function\n\u003c\/li\u003e\u003cli\u003eFolate contributes to the normal function of the immune system\n\u003c\/li\u003e\u003cli\u003eFolate contributes to the reduction of tiredness and fatigue\n\u003c\/li\u003e\u003cli\u003eFolate plays a role in the process of cell division\n\u003cp\u003eMethyltetrahydrofolate is the methyl group donor required for the conversion of homocysteine to methionine. Folate and vitamin B\u003csub\u003e12\u003c\/sub\u003e are also required for the synthesis of methionine and \u003cem\u003eS\u003c\/em\u003e-Adenosylmethionine ( SAMe). SAMe is the common methyl donor required for the maintenance of methylation patterns in DNA that determine gene expression and DNA conformation (\u003ca href=\"http:\/\/mutage.oxfordjournals.org\/content\/18\/1\/81.full#ref-29\"\u003eZingg and Jones, 1997\u003c\/a\u003e).\n5MTHF is also required for normal neurotransmitter production, such as serotonin, domamine, melatonin, adrenalin and noradrenalin. So is a good mood support and cardiovascular support.\n\u003c\/p\u003e\n\u003cp\u003e5 MTHF is also important as the most bioavailable form of Folic Acid during pregnancy. It plays an important role in preventing chromosome breakage and hypomethylation of DNA. If folate deficiency occurs Uracil is incorporated into DNA instead of Thiamine(\u003ca href=\"http:\/\/mutage.oxfordjournals.org\/content\/18\/1\/81.full#ref-10\"\u003eEto and Krumdieck, 1986\u003c\/a\u003e; \u003ca href=\"http:\/\/mutage.oxfordjournals.org\/content\/18\/1\/81.full#ref-27\"\u003eWagner, 1995\u003c\/a\u003e; \u003ca href=\"http:\/\/mutage.oxfordjournals.org\/content\/18\/1\/81.full#ref-12\"\u003eFenech, 2001\u003c\/a\u003e). This can lead to mutations.\n\u003c\/p\u003e\n\u003ch3\u003eRecommended Dosage\u003c\/h3\u003e\n\u003cp\u003e1 capsule per day with food\n\u003c\/p\u003e\n\u003cp\u003eThis product is \u003cb\u003esuitable for vegetarians and vegans\u003cb\u003e.\u003c\/b\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/li\u003e","brand":"Metabolics","offers":[{"title":"Default Title","offer_id":48071778074956,"sku":"METHYLTHF60C","price":24.7,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/6623\/0092\/files\/methyltetrahydrofolate-60-capsules-2341179.png?v=1771514158"},{"product_id":"memorymax-pot-of-150-capsules","title":"Memorymax - 150 Capsules","description":"\u003ch3\u003eMetabolics Memorymax\u003c\/h3\u003e\n\u003cp\u003eMemorymax is a compound formula designed to be taken alongside Metabolics B Complex and Metablics Krill Oil or Omega 3 capsules.\u003c\/p\u003e\n\u003cp\u003eThis trio of supplements contains ingredients which provide excellent support for the brain and nervous system.\u003c\/p\u003e\n\u003cp\u003eMemorymax is an unique blend of the following ingredients:\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMagnesium \u003c\/strong\u003eis a vitally important nutrient, having numerous contributions to normal functioning of the nervous system, transmission of nerve impulses, psychological functioning and cell division. If Magnesium ion levels are low, random firing of the nerves and nerve hyper-excitability will result. Magnesium ions are also needed for cell signalling which is vital for the brain. Memory loss is thought to be associated with diminution of synaptic plasticity in the brain and that low levels of magnesium contribute to this. Research suggests that Magnesium enhances both short term synaptic facilitation and long term potentiation, improving memory and learning functions (Slutsky, Albumaria et al. 2010).\u003c\/p\u003e\n\u003cp\u003eMagnesium deficiency has been associated with depression and neuropsychiatric disorders. Deficiency has also been associated with the oxidative stress resulting from the aging process (Barbagallo, Belvedere et al. 2009).\u003c\/p\u003e\n\u003cp\u003eMagnesium is needed for the Magnesium dependent enzyme sphingomyelinase which is responsible for producing sphingomyelin, part of the fatty acid layer of cell membranes particularly in the brain.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCholine\u003c\/strong\u003econtributes to normal lipid metabolism. As a precursor of phospholipids, choline is vital for both the structural integrity and fluidity of cell membranes. The major phospholipid in cell walls is phosphatidylcholine, which is made up of a choline head and a lipid or fat tail. Membrane dynamics influence cell signalling by controlling the interaction and location of membrane proteins (Lipidomics Gateway, 2009).\u003c\/p\u003e\n\u003cp\u003ePhosphatidyl Choline accounts for more than 50% of mammalian cell membrane phospholipids and more than 30% of total cellular lipid content. Phosphatidyl choline is used to make the brain chemical acetylcholine. Acetylcholine receptors play a role in encoding new memories. It may enhance encoding by several mechanisms including modification of synapse and by enhancing long term potentiation (Hasselmo, 2006).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eResveratrol\u003c\/strong\u003eis a naturally occurring compound, found principally in red grape products such as red wine. Resveratrol has been found to suppress the activity of cholinesterase, an enzyme that destroys acetylcholine, restoring acetylcholine function (Byeong, Eun, et al. 2012).\u003c\/p\u003e\n\u003cp\u003eThere is presently (as of June 2012) a phase 2 clinical trial investigation which looks into the effects of resveratrol on individuals with mild to moderate dementia related to alzheimers, in progress.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAstaxanthin\u003c\/strong\u003eis a super carotenoid derived from algae called Haematococcus Pluvialis. It is thousands of times more powerful than any other carotenoids such as beta carotenoid. Carotenoids are naturally occurring antioxidants.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eGlutathione (Reduced)\u003c\/strong\u003e. During the aging process free radical damage appears and when a certain level is reached neurodegenerative disease can occur. The cumulative effect of oxidative stress leads to reduced levels of the antioxidant glutathione in the brain. The highest level of glutathione is found in the mitochondria of the neuron where 95% of free radicals are produced. If glutathione levels are low, perhaps due to a result of infection, diabetes, stroke, toxic metal exposure (such as lead or aluminium) or even high levels of glutamate (in MSG), then inflammation and free radicals can result. Free radicals can disrupt or kill neurones, and neurotoxicity has been found to be a major contributory factor in “loss of memory” diseases such as Alzhiemers Disease (AD).\u003c\/p\u003e\n\u003cp\u003eWhen taken as a supplement, N Acetyl Cysteine (the precursor to glutathione) was found to restore plasticity in the aged animal brain to the younger adult state (Robillard, Gordon, et al. 2011).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoEnzyme Q10 (ubiquinone)\u003c\/strong\u003eis present in most cells, primarily in the mitochondria where it is involved in the electron transport chain. Its primary function is in the generation of energy and of prime importance in the brain in the preservation of memory function. Research has shown that administering an analogue of ubiquinone (idebenone) to patients aged between 60-80 years with Alzheimers type symptoms, demonstrated significant improvement in the memory of people with dementia and improvement in memory impairment of people without dementia (Voronkova and Meleshkov, 2009).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoEnzyme Q10\u003c\/strong\u003ecan easily penetrate not only the cell, but the mitochondria, providing antioxidant protection to neurones, preserving mitochondrial membrane potential during oxidative stress, so preserving memory pathways.\u003c\/p\u003e\n\u003cp\u003eAlpha Lipoic Acid (Thiotic acid) is a fatty acid found in every cell in the body. The body uses alpha lipoic acid to convert glucose into energy and can easily cross the blood-brain barrier making it able to target mitochondria as an antioxidant. Alpha lipoic acid has also been shown to increase acetylcholine production, an important neurotransmitter involved in memory. In July 2012 an online article was published in the Journal of Alzheimers talking about Alpha Lipoic acid being given to mice looking at the effects on memory. Alpha Lipoic Acid and Carnitine together can cross the blood-brain barrier. Studies have been conducted on mice to try and discover more about how these two nutrients affect temporal and spatial memory (Shenk, Liu, et al. 2009).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBiotin\u003c\/strong\u003eis important for normal functioning of the nervous system. It is needed for the Propionyl-CoA carboxylase enzyme that contributes to the production of cholesterol which is essential for cell membranes. Also cholesterol is needed in the brain for the production of neurotransmitters, the chemicals that transmit nerve impulses. Biotin is a cofactor in other carboxylase enzymes, particularly important is Acetyl-CoA carboxylase 2 that regulates mitochondrial fatty acid oxidation. The enzyme pyruvate carboxylase is critical in forming glucose in the brain from sources other than carbohydrates. Biotin contributes to normal psychological function including normal mental performance, learning, memory and reasoning.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTurmeric (95% curcuminoids)\u003c\/strong\u003eis a spice that has been used for thousands of years in Indian medicine. Growing evidence suggests that oxidative stress, free radicals and beta amyloid in Alzheimers are caused by factors such as metal toxicity and abnormal inflammatory reactions. Curcumin has been extensively researched in patients with Alzheimer’s (Mishra and Palanivelu, 2008). Particular interest has been taken into the epigenetic effects of curcuminoids. Experiments using animal models have also been conducted to ascertain the effects of curcumin on impaired cognition and neuronal plasticity induced by chronic stress (Xu, Lin, et al. 2009).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLutein\u003c\/strong\u003e- A carotenoid which has been the focus of much evaluation into its effects on cognition when taken in conjunction with DHA (Johnson and McDonald, 2008).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVitamin E\u003c\/strong\u003econtributes to the protection of cells from oxidative stress that causes free radical damage. Vitamin E protects lipid cell membranes from oxidative damage that is particularly important in the brain, as 60% of the brain is fat. Vitamin E acts as a chain breaking antioxidant preventing lipid destruction. Deficiency of Vitamin E is serious, producing neurological symptoms including memory loss (Pham and Plakogiannis, 2005)(Takatsu and Owada, 2009).\u003c\/p\u003e\n\u003cp\u003eFor optimum effectivity Memorymax is recommended to be taken with \u003ca rel=\"noopener\" href=\"https:\/\/www.metabolics.com\/b-complex-pot-of-180-capsules.html\" target=\"_blank\"\u003eMetabolics B Complex\u003c\/a\u003e and \u003ca rel=\"noopener\" href=\"https:\/\/www.metabolics.com\/omega-3-pot-of-90-capsules.html\" target=\"_blank\"\u003eMetabolics Omega 3\u003c\/a\u003e or \u003ca rel=\"noopener\" href=\"https:\/\/www.metabolics.com\/krill-oil-pot-of-60-capsules.html\" target=\"_blank\"\u003eKrill Oil\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003ePlease note: The European Food Safety Authority is examining the potential for a link between the consumption of alpha lipoic acid, and the development of insulin autoimmune disease in individuals with certain genetic polymorphisms. Whilst the EFSA works to establish whether or not a link exists, anyone who thinks they could be at risk of insulin autoimmune disease should seek professional medical advice before purchasing this product\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003eBarbagallo M, Belvedere M, Dominguez LJ. 2009. \u003cem\u003eMagnesium homeostasis and aging.\u003c\/em\u003eMagnesium research: official organ of the International Society for the Development of Research on Magnesium. 22(4):235-46.\u003c\/p\u003e\n\u003cp\u003eByeong Tak Jeon, Eun Ae Jeong, Hyun Joo Shin, Younghyurk Lee, Dong Hoon Lee, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, and Gu Seob Roh. 2012. \u003cem\u003eResveratrol Attenuates Obesity-Associated Peripheral and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet.\u003c\/em\u003eDiabetes. 61(6): 1444–1454.\u003c\/p\u003e\n\u003cp\u003eBy Voronkova KV, Meleshkov MN. 2009. Neurosci Behav Physiol. \u003cem\u003eUse of Noben (idebenone) in the treatment of dementia and memory impairments without dementia.\u003c\/em\u003e39(5):501-6.\u003c\/p\u003e\n\u003cp\u003eJohnson EJ, McDonald K, Caldarella SM, Chung HY, Troen AM, Snodderly DM. 2008. \u003cem\u003eCognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women.\u003c\/em\u003eNutr Neurosci. 11(2):75-83.\u003c\/p\u003e\n\u003cp\u003eLipidomics Gateway. 2009. Phosphatidylcholine. 10.1038.\u003c\/p\u003e\n\u003cp\u003eMichael E Hasselmo. 2006. \u003cem\u003eThe Role of Acetylcholine in Learning and Memory.\u003c\/em\u003ePub Curr Opin Neurobiol. 16(6): 710–715.\u003c\/p\u003e\n\u003cp\u003ePham, Plakogiannis. 2005. \u003cem\u003eVitamin E supplementation in Alzheimer's disease, Parkinson's disease, tardive dyskinesia, and cataract: Part 2.\u003c\/em\u003eAnn Pharmacother. 39(12):2065-72.\u003c\/p\u003e\n\u003cp\u003eRobillard JM, Gordon GR, Choi HB, Christie BR, MacVicar BA. \u003cem\u003eGlutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult.\u003c\/em\u003ePLoS One. 6(5):e20676.\u003c\/p\u003e\n\u003cp\u003eShenk JC, Liu J, Fischbach K, Xu K, Puchowicz M, Obrenovich ME, Gasimov E, Alvarez LM, Ames BN, Lamanna JC, Aliev G. 2009. \u003cem\u003eThe effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.\u003c\/em\u003eJ Neurol Sci. 15;283(1-2):199-206.\u003c\/p\u003e\n\u003cp\u003eShrikant Mishra and Kalpana Palanivelu. 2008. \u003cem\u003eThe effect of curcumin (turmeric) on Alzheimer's disease: An overview.\u003c\/em\u003eAnn Indian Acad Neurol. 11(1): 13–19.\u003c\/p\u003e\n\u003cp\u003eSlutsky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G. 2010. \u003cem\u003eEnhancement of learning and memory by elevating brain magnesium.\u003c\/em\u003eNeuron. 28;65(2):165-77.\u003c\/p\u003e\n\u003cp\u003eTakatsu H, Owada K, Abe K, Nakano M, Urano S. 2009. \u003cem\u003eEffect of vitamin E on learning and memory deficit in aged rats.\u003c\/em\u003eJ Nutr Sci Vitaminol (Tokyo). 55(5):389-93.\u003c\/p\u003e\n\u003cp\u003eXu Y, Lin D, Li S, Li G, Shyamala SG, Barish PA, Vernon MM, Pan J, Ogle WO. 2009. \u003cem\u003eCurcumin reverses impaired cognition and neuronal plasticity induced by chronic stress.\u003c\/em\u003eNeuropharmacology. 57(4):463-71.\u003c\/p\u003e\n\u003cp\u003eThis product is \u003cstrong\u003esuitable for vegetarians and vegans\u003cstrong\u003e.\u003c\/strong\u003e\u003c\/strong\u003e\u003c\/p\u003e","brand":"Metabolics","offers":[{"title":"Default Title","offer_id":48071781122380,"sku":"MEMAX150C","price":49.59,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/6623\/0092\/files\/memorymax-150-capsules-9339132.png?v=1771950555"},{"product_id":"acetyl-l-carnitine-pot-of-60-capsules","title":"Acetyl L. Carnitine - 60 capsules","description":"\u003cp\u003eIn Stock - Order by 3pm for same day dispatch\u003c\/p\u003e\n\u003ch2\u003eWhat is Acetyl L Carnitine?\u003c\/h2\u003e\n\u003cp\u003eAcetyl L Carnitine (known as ALC or ALCAR) is a derivative of Carnitine which is found naturally in high protein foods such as meat and eggs.\u003c\/p\u003e\n\u003cp\u003eAcetyl L Carnitine is a highly bioavailable form of L-Carnitine, more easily absorbed from the gut and due to the presence of an acetyl group, is able to cross the blood brain barrier.\u003c\/p\u003e\n\u003ch2\u003eWhat is Acetyl L Carnitine good for?\u003c\/h2\u003e\n\u003cp\u003eIt facilitates the transport of fatty acids into the mitochondria (the powerhouses of your cells) where they are burned up and used as fuel - helping mitochondria to burn fat and create more energy. Mitochondria are abundant both in the brain and muscles.\u003c\/p\u003e\n\u003cp\u003eAcetyl L-Carnitine assists with the critical conversion of choline into acetylcholine. Acetylcholine itself is an abundant neurotransmitter, responsible for communication between the nerves and muscles, sensation of pain, learning and memory formation and in the regulation of the endocrine system.\u003c\/p\u003e\n\u003ch2\u003eWho is Acetyl L Carnitine for?\u003c\/h2\u003e\n\u003cp\u003eDue to its role in brain and muscle support, it is important to maintain dietary intake of acetyl l carnitine but this is especially true throughout the ageing process.\u003c\/p\u003e\n\u003cp\u003eWhile the ageing process affects everyone’s body and brains differently, it is widely accepted that our brains gradually decline as we get older. A healthy balanced diet and physical activity are recommended to reduce the risk of cognitive decline.\u003c\/p\u003e\n\u003ch2\u003eWhy use Metabolics Acetyl L Carnitine\u003c\/h2\u003e\n\u003cp\u003eUnlike some food supplement manufacturers, Metabolics prides itself on formulating and manufacturing its products as few ingredients as possible, so that only the active ingredients are used where possible. Metabolics Acetyl L Carnitine contains only acetyl l carnitine and the capsule, to maximise bioavailability and ensure you know what you are putting into your body.\u003c\/p\u003e\n\u003cp\u003eAs a result, this is also means that this product is suitable for vegetarian and vegan diets.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.metabolics.com\/blog\/how-are-your-supplements-made\/\"\u003eFood supplements made\u003c\/a\u003e to GMP standards.\u003c\/p\u003e\n\u003cp\u003eMade in our \u003ca href=\"https:\/\/www.metabolics.com\/video-production-tour\"\u003eclean room facility\u003c\/a\u003e, here in the UK.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.metabolics.com\/metabolics-accreditations\"\u003eISO accredited\u003c\/a\u003e ISO:9001 and ISO:14001 accredited.\u003c\/p\u003e","brand":"Metabolics","offers":[{"title":"Default Title","offer_id":48071785185612,"sku":"ACETI60C","price":39.64,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/6623\/0092\/files\/acetyl-l-carnitine-60-capsules-1664519.png?v=1771518077"},{"product_id":"sunflower-lecithin-powder","title":"Sunflower Lecithin Powder - 200g","description":"\u003ch3\u003eSunflower Lecithin Powder\u003c\/h3\u003e\n\u003cp\u003eThis de-oiled sunflower lecithin is a high quality Soy free, GMO free alternative supply of important phospholipids. It is also certified Kosher and Halal EU. This Sunflower Lecithin powder from sunflower seeds contains:\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e25% Phosphatidyl Choline\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e12% Phosphatidyl Ethanolamine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e20% Phosphatidyl Inositol\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e3% Phosphatidic Acid \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ePhospholipids make up the outer bilayer of cell membranes. Phosphatidyl choline is the most commonly found phospholipid in human cells. Phospholipids play an important role in transporting lipids and cholesterol and absence of phospholipids result in cholesterol and other fats accumulation in the liver.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhosphatidyl Choline\u003c\/strong\u003e is also a source of choline from which further phospholipids are synthesised and phosphorus. Phosphorus contributes to normal energy production in addition to normal function of cell membranes. It is also important for the maintenance of normal bones and teeth.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhoshatidyl Ethanolamine\u003c\/strong\u003e is found in all living cells, particularly in the white matter of the brain, nerve tissue and spinal cord.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhosphatidyl Inositol\u003c\/strong\u003e is also present in all tissues and cell types and constitutes about 10% of the phospholipids of the brain.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhosphatidic Acid \u003c\/strong\u003eis also an important component of cell membranes. It acts as a signalling lipid and can influence curvature of the cell membrane.\u003c\/p\u003e\n\u003cp\u003eAs with all Metabolics products it is 100% pure and does not contain any artificial preservatives, additives, flavours, colours, fillers or excipients (flowing agents).\u003c\/p\u003e\n\u003cp\u003eThis powder can be easily mixed with water and as it has a bland taste can be mixed with juices to provide an excellent source of phosphatidyl choline.\u003c\/p\u003e\n\u003cp\u003eEach 2.5gm scoop provides on average 625mg phosphatidyl choline. Each pot provides 80 scoops.\u003c\/p\u003e\n\u003cp\u003eThis product is \u003cstrong\u003esuitable for vegans\u003cstrong\u003e.\u003c\/strong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cstrong\u003eThis product replaces Phosphatidyl Choline 60 Capsules and Phospholipid Complex 100ml. If you need more information, please \u003ca href=\"https:\/\/www.metabolics.com\/contacts\"\u003eget in touch\u003c\/a\u003e.\u003c\/strong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cstrong\u003eNote: \u003cspan style=\"color: #ff0000;\"\u003eThis product is experiencing a temporary price increase.\u003c\/span\u003e A lot of the worlds supply of sunflower products are grown in Ukraine which is obviously affecting availability at present. As soon as the raw material costs come down again, so will the price of this product.\u003c\/strong\u003e\u003c\/strong\u003e\u003c\/p\u003e","brand":"Metabolics","offers":[{"title":"Default Title","offer_id":48071786398028,"sku":"SFL200G","price":52.21,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/6623\/0092\/files\/sunflower-lecithin-powder-200g-7097912.png?v=1771934753"},{"product_id":"magnesium-l-threonate","title":"Magtein® Magnesium L-Threonate Capsules","description":"\u003cp class=\"MsoNormal\"\u003eThe patented form of magnesium L-threonate, developed by MIT researchers. 2,000mg per daily serving, made to Metabolics' stringent quality standards.\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e \u003c\/p\u003e","brand":"Metabolics","offers":[{"title":"Default Title","offer_id":48817155244364,"sku":"MAG_THRE120C","price":45.05,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/6623\/0092\/files\/magtein-magnesium-l-threonate-capsules-7949698.png?v=1788826947"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/6623\/0092\/collections\/cognitive-and-memory-support-1181288_700ee92e-cb53-4155-9ca7-8e86a5cc82cd.jpg?v=1790266620","url":"https:\/\/www.metabolics.com\/collections\/brain-health.oembed","provider":"Metabolics","version":"1.0","type":"link"}