{"product_id":"liquid-methylfolate","title":"Liquid Methylfolate (5-MTHF), 1000µg Active Folate | Methyltetrahydrofolate | 100ml","description":"\u003cp\u003eFolic Acid needs to be converted (methylated) in the intestines and liver to its active form 5-methyltetrahydrofolate (5-MeTHF) which is found in the blood and utilised by tissues. A very high percentage of people (60% in USA), have a genetic enzyme defect preventing them from converting Folic Acid to 5-Methyltetrahydrofolate, so 5 MTHF may be the only effective form of Folate supplementation for these people.\u003c\/p\u003e\n\u003ch3\u003eWhy Use Metabolics Methyltetrahydrofolate?\u003c\/h3\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFolate contributes to maternal tissue growth during pregnancy\u003c\/li\u003e\n\u003cli\u003eFolate contributes to normal amino acid synthesis\u003c\/li\u003e\n\u003cli\u003eFolate contributes to normal red blood formation\u003c\/li\u003e\n\u003cli\u003eFolate contributes to normal homocysteine metabolism\u003c\/li\u003e\n\u003cli\u003eFolate contributes to normal psychological function\u003c\/li\u003e\n\u003cli\u003eFolate contributes to the normal function of the immune system\u003c\/li\u003e\n\u003cli\u003eFolate contributes to the reduction of tiredness and fatigue\u003c\/li\u003e\n\u003cli\u003eFolate plays a role in the process of cell division\u003cbr\u003e\n\u003cp\u003eMethyltetrahydrofolate is the methyl group donor required for the conversion of homocysteine to methionine. Folate and vitamin B\u003csub\u003e12\u003c\/sub\u003e are also required for the synthesis of methionine and \u003cem\u003eS\u003c\/em\u003e-Adenosylmethionine ( SAMe). SAMe is the common methyl donor required for the maintenance of methylation patterns in DNA that determine gene expression and DNA conformation (\u003ca href=\"http:\/\/mutage.oxfordjournals.org\/content\/18\/1\/81.full#ref-29\"\u003eZingg and Jones, 1997\u003c\/a\u003e).\u003cbr\u003e5MTHF is also required for normal neurotransmitter production, such as serotonin, dopamine, melatonin, adrenalin and noradrenalin. So is a good mood support and cardiovascular support.\u003c\/p\u003e\n\u003cp\u003e5 MTHF is also important as the most bioavailable form of Folic Acid during pregnancy. It plays an important role in preventing chromosome breakage and hypomethylation of DNA. If folate deficiency occurs Uracil is incorporated into DNA instead of thymine (\u003ca href=\"http:\/\/mutage.oxfordjournals.org\/content\/18\/1\/81.full#ref-10\"\u003eEto and Krumdieck, 1986\u003c\/a\u003e; \u003ca href=\"http:\/\/mutage.oxfordjournals.org\/content\/18\/1\/81.full#ref-27\"\u003eWagner, 1995\u003c\/a\u003e; \u003ca href=\"http:\/\/mutage.oxfordjournals.org\/content\/18\/1\/81.full#ref-12\"\u003eFenech, 2001\u003c\/a\u003e). This can lead to mutations.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Metabolics","offers":[{"title":"100ml","offer_id":48071719813452,"sku":"MTHF100T","price":24.7,"currency_code":"GBP","in_stock":true},{"title":"250ml Refill","offer_id":48071719846220,"sku":"MTHF250T","price":30.05,"currency_code":"GBP","in_stock":true},{"title":"500ml Refill","offer_id":48071719878988,"sku":"MTHF500T","price":49.01,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/6623\/0092\/files\/methyltetrahydrofolate-liquid-2507906.png?v=1768344020","url":"https:\/\/www.metabolics.com\/products\/liquid-methylfolate","provider":"Metabolics","version":"1.0","type":"link"}