Magtein® is a patented, clinically studied form of magnesium L-threonate, based on pioneering MIT research into increasing magnesium levels in the brain. 2,000 mg per daily serving, made to Metabolics’ stringent quality standards.

Magnesium is an essential mineral involved in hundreds of enzymatic reactions throughout the body, including those involved in nerve signalling, neurotransmission, energy production, muscle function and electrolyte balance.

Magtein® was developed through research investigating magnesium availability within the central nervous system and has since been investigated in published preclinical and human clinical studies evaluating brain magnesium status, cognitive performance, sleep quality and daytime functioning.

Magtein® Magnesium L-Threonate may be suitable for:

• Adults wishing to support normal psychological & normal nervous system function.
• Adults wishing to reduce tiredness and fatigue. 
• Those looking for a specialist, patented form of supplemental magnesium. 
• Individuals seeking a clinically researched magnesium ingredient with published studies investigating cognitive performance, sleep quality and daytime functioning.

Genuine patented Magtein®

Contains genuine Magtein®, the original patented magnesium L-threonate ingredient, currently the only authorised source of magnesium L-threonate under the applicable UK and EU novel food authorisations.

Clinically researched

Magtein® magnesium L-threonate has been investigated in human clinical studies assessing magnesium status and several areas of cognitive performance.

In a randomised, double-blind, placebo-controlled study involving adults aged 50–70 with cognitive impairment, participants received either a formulation containing magnesium L-threonate or placebo for 12 weeks.

The study assessed executive function, working memory, attention and episodic memory. The magnesium L-threonate group showed a statistically significant improvement in the study’s composite measure of overall cognitive ability compared with placebo. The study also reported an overall treatment effect for executive function, while results for individual assessments of working memory, attention and episodic memory varied between time points. 

Magnesium contributes to normal psychological function and normal functioning of the nervous system. It plays an essential role in nerve signalling, neurotransmission and energy production.

Magtein® magnesium L-threonate was developed through research investigating magnesium availability within the central nervous system. Preclinical studies explored its effects on brain magnesium concentrations, synaptic plasticity and memory-related processes, leading to subsequent human clinical research.

A randomised, double-blind, placebo-controlled clinical trial evaluated a magnesium L-threonate-containing formulation in adults aged 50–70 years with cognitive impairment over 12 weeks. The study assessed executive function, working memory, attention and episodic memory, reporting a statistically significant improvement in overall cognitive ability, measured using a composite score across the four cognitive domains. An overall treatment effect was also observed for executive function, while working memory improved significantly at six weeks. Improvements in attention and episodic memory were not statistically significant compared with placebo. 

Magtein® has also been investigated in clinical studies evaluating sleep quality, daytime functioning, stress and anxiety. In adults with self-reported sleep problems, supplementation was associated with improvements in several objective measures of sleep, together with improvements in mental alertness, mood and daytime functioning. A separate 12-week study in adults with self-reported stress and anxiety reported significant improvements from baseline in self-rated stress and anxiety, together with a clinically meaningful reduction in the Hamilton Anxiety Rating Scale (HAM-A) fear sub-score. Further research is needed to confirm these findings. 

Further reading

1. Liu G, Weinger JG, Lu Z-L, Xue F, Sadeghpour S. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Alzheimer's Disease. 2016;49:971–990. 
2. Slutsky I, et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 2010;65(2):165–177.
3. Hausenblas HA, Lynch T, Hooper S, Shrestha A, Rosendale D, Gu J. Magnesium L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Medicine: X. 2024;8:100121
4. Hewlings SJ, Kalman DS. A Randomized, Double-Blind, Placebo-Controlled, Comparator Trial Evaluating Magtein® Magnesium Supplement on Quality of Life as Related to Levels of Stress, Anxiety, Fear and Other Indicators. EC Nutrition. 2022;17(3):7–14