FREE UK delivery on orders £50+
For practitioners, by practitioners
Highest quality, GMP certified
Family owned, British made

5-Hydroxytryptophan (Pot of 90 capsules)


5-Hydroxytryptophan (5-HTP) is a metabolite of tryptophan and is crucial to the synthesis of serotonin.

Full product description

Suitable for vegetarians: Yes

Suitable for vegans: Yes

In Stock - Order by 3pm for same day dispatch

What is Metabolics 5-Hydroxytryptophan?

5-Hydroxytryptophan (5HTP) is an amino acid involved in converting the amino acid L Tryptophan to Serotonin, which is a neurotransmitter or "messenger brain chemical" associated with the regulation of sleep. Serotonin then goes on to make melatonin in the pineal gland in the brain and adequate amounts of melatonin, which is an antioxidant, also help us to sleep.

There are no dietary sources of 5-Hydroxytryptophan, Metabolics 5-Hydroxytryptophan is derived from the West African Griffonia tree, which is a climbing evergreen shrub that produces green flowers and, later, black seed pods and is the only natural source of 5Hydroxytryptophan available.

Indigenous people of west Africa have used the leaf sap of these shrubs for years to aid the healing of burns and other such uses and the chopped up bark has been used for sores but the seeds are the most sought after element of the plant.

What is Metabolics 5-Hydroxytryptophan for?

5-Hydroxytryptophan is very well absorbed by the body and taken into the bloodstream. It easily crosses the blood brain barrier and is readily available for serotonin synthesis in the central nervous system.

The synthesis of serotonin from 5 Hydroxytryptophan requires vitamin B6, so this formula has the addition of Pyridoxal 5 Phosphate, the active form of B6.

As serotonin and melatonin are associated with a healthy sleeping pattern, 5-Hydroxytryptophan is widely used for helping people sleep as well as regulating mood and easing anxiety.

Who is Metabolics 5-Hydroxytryptophan for?

5-Hydroxytryptophan is a convenient way of supporting a natural sleeping pattern and regulating mood. L-tryptophan can be obtained through dietary sources such as turkey, chicken, pumpkin seeds, spinach, milk, and bananas, but 5-Hydroxytryptophan is produced by the body and some people, therefore, find it beneficial to supplement this nutrient if their body is not producing enough.

Therefore, this supplement may be useful for people who either do not produce enough 5-Hydroxytryptophan or are unable to consume dietary sources of l-tryptophan.

There are also some studies that suggest 5-Hydroxytryptophan may be useful for weight management support, although more research is needed to draw conclusive results.

Why use Metabolics 5-Hydroxytryptophan

Metabolics prides itself on producing food supplements with simple ingredient lists so that there are minimal ingredients that have the potential to interfere with the active ingredients.

As 5-Hydroxytryptophan is involved with serotonin and melatonin production it is very important to consult a healthcare practitioner prior to adding this food supplement to your diet. This is particularly true if you are taking medication such as sleep or mood regulating medication, which could see you producing too much serotonin or melatonin.

Food supplements made to GMP standards.

Made in our clean room facility, here in the UK.

ISO accredited ISO:9001 and ISO:14001 accredited.



"So far so good, I think it's helping me sleep and relax."
Gary Campion | Posted 10 months ago | Read full review
"My client is very happy with this product."
julia polyblank | Posted 2 years ago | Read full review
"Just started these and they seem to work well"
Trusted Customer | Posted 3 years ago | Read full review
"To early to tell if working.."
Daryl Allison | Posted 3 years ago | Read full review
"Excellent product if I could get my hands on it"
Trusted Customer | Posted 3 years ago | Read full review
Each capsule contains
Vitamin B6
2.3 mg
Griffonia seed extract(5HTP)
†Nutrient Reference Value (NRV*) not established

Cellulose, Griffonia seed extract, Hydroxypropyl Methylcellulose (capsule), Pyridoxal 5 Phosphate

No Gluten Containing IngredientsNo Gluten Containing Ingredients
No Nut Containing IngredientsNo Nut Containing Ingredients
Recommended dose 1 capsule per day with food. The stated recommended dose can be changed as directed by your healthcare practitioner. Do not exceed this recommended dose. Consume within 3 months of opening.
If pregnant or breast feeding, consult your health care practitioner before using. This product should not be used as a substitute for a varied diet.
Store in a cool, dry place out of reach of children.
Serving size: 1 capsule