MemoryMax is a multi-ingredient nutritional formulation combining essential micronutrients, such as B-vitamins, with a range of botanicals and additional nutritional compounds. The ingredients have been selected for their relevance to normal nervous system and psychological function, cellular metabolism, and broader biochemical processes, all of which form part of the complex physiological processes involved in memory.

This formulation brings together a diverse nutrient profile designed to complement everyday dietary intake as part of a balanced lifestyle.

Individuals interested in nutrients relevant to normal nervous system and psychological physiology, including processes involved in memory and brain function

People seeking formulations aligned with everyday neurological and metabolic processes within the brain

Those who value combinations of botanicals and micronutrients selected for their relevance to brain-related physiological processes

Anyone looking for clean, practitioner-formulated products to complement their daily routine

Metabolics MemoryMax is formulated with a focus on ingredient quality, balance, and thoughtful composition, within the broader area of brain health and neurological nutrition. It combines selected micronutrients and botanicals in a clean, additive-free formula designed for consistent daily use, without stimulants or unnecessarily high doses.

Developed with practitioner input and manufactured to stringent quality and GMP standards, MemoryMax reflects Metabolics’ commitment to well-characterised ingredients, careful formulation, and evidence-informed nutritional practice in this area.

Magnesium is a vitally important nutrient, having numerous contributions to normal functioning of the nervous system, transmission of nerve impulses, psychological functioning and cell division. If Magnesium ion levels are low, random firing of the nerves and nerve hyper-excitability will result. Magnesium ions are also needed for cell signalling which is vital for the brain. Memory loss is thought to be associated with diminution of synaptic plasticity in the brain and that low levels of magnesium contribute to this. Research suggests that Magnesium enhances both short term synaptic facilitation and long term potentiation, improving memory and learning functions (Slutsky, Albumaria et al. 2010).

Magnesium deficiency has been associated with depression and neuropsychiatric disorders. Deficiency has also been associated with the oxidative stress resulting from the aging process (Barbagallo, Belvedere et al. 2009).

Magnesium is needed for the Magnesium dependent enzyme sphingomyelinase which is responsible for producing sphingomyelin, part of the fatty acid layer of cell membranes particularly in the brain.

Cholinecontributes to normal lipid metabolism. As a precursor of phospholipids, choline is vital for both the structural integrity and fluidity of cell membranes. The major phospholipid in cell walls is phosphatidylcholine, which is made up of a choline head and a lipid or fat tail. Membrane dynamics influence cell signalling by controlling the interaction and location of membrane proteins (Lipidomics Gateway, 2009).

Phosphatidyl Choline accounts for more than 50% of mammalian cell membrane phospholipids and more than 30% of total cellular lipid content. Phosphatidyl choline is used to make the brain chemical acetylcholine. Acetylcholine receptors play a role in encoding new memories. It may enhance encoding by several mechanisms including modification of synapse and by enhancing long term potentiation (Hasselmo, 2006).

Resveratrol is a naturally occurring compound, found principally in red grape products such as red wine. Resveratrol has been found to suppress the activity of cholinesterase, an enzyme that destroys acetylcholine, restoring acetylcholine function (Byeong, Eun, et al. 2012).

There is presently (as of June 2012) a phase 2 clinical trial investigation which looks into the effects of resveratrol on individuals with mild to moderate dementia related to alzheimers, in progress.

Astaxanthinis a super carotenoid derived from algae called Haematococcus Pluvialis. It is thousands of times more powerful than any other carotenoids such as beta carotenoid. Carotenoids are naturally occurring antioxidants.

Glutathione (Reduced). During the aging process free radical damage appears and when a certain level is reached neurodegenerative disease can occur. The cumulative effect of oxidative stress leads to reduced levels of the antioxidant glutathione in the brain. The highest level of glutathione is found in the mitochondria of the neuron where 95% of free radicals are produced. If glutathione levels are low, perhaps due to a result of infection, diabetes, stroke, toxic metal exposure (such as lead or aluminium) or even high levels of glutamate (in MSG), then inflammation and free radicals can result. Free radicals can disrupt or kill neurones, and neurotoxicity has been found to be a major contributory factor in “loss of memory” diseases such as Alzhiemers Disease (AD).

When taken as a supplement, N Acetyl Cysteine (the precursor to glutathione) was found to restore plasticity in the aged animal brain to the younger adult state (Robillard, Gordon, et al. 2011).

CoEnzyme Q10 (ubiquinone)is present in most cells, primarily in the mitochondria where it is involved in the electron transport chain. Its primary function is in the generation of energy and of prime importance in the brain in the preservation of memory function. Research has shown that administering an analogue of ubiquinone (idebenone) to patients aged between 60-80 years with Alzheimers type symptoms, demonstrated significant improvement in the memory of people with dementia and improvement in memory impairment of people without dementia (Voronkova and Meleshkov, 2009).

CoEnzyme Q10can easily penetrate not only the cell, but the mitochondria, providing antioxidant protection to neurones, preserving mitochondrial membrane potential during oxidative stress, so preserving memory pathways.

Alpha Lipoic Acid (Thiotic acid) is a fatty acid found in every cell in the body. The body uses alpha lipoic acid to convert glucose into energy and can easily cross the blood-brain barrier making it able to target mitochondria as an antioxidant. Alpha lipoic acid has also been shown to increase acetylcholine production, an important neurotransmitter involved in memory. In July 2012 an online article was published in the Journal of Alzheimers talking about Alpha Lipoic acid being given to mice looking at the effects on memory. Alpha Lipoic Acid and Carnitine together can cross the blood-brain barrier. Studies have been conducted on mice to try and discover more about how these two nutrients affect temporal and spatial memory (Shenk, Liu, et al. 2009).

Biotinis important for normal functioning of the nervous system. It is needed for the Propionyl-CoA carboxylase enzyme that contributes to the production of cholesterol which is essential for cell membranes. Also cholesterol is needed in the brain for the production of neurotransmitters, the chemicals that transmit nerve impulses. Biotin is a cofactor in other carboxylase enzymes, particularly important is Acetyl-CoA carboxylase 2 that regulates mitochondrial fatty acid oxidation. The enzyme pyruvate carboxylase is critical in forming glucose in the brain from sources other than carbohydrates. Biotin contributes to normal psychological function including normal mental performance, learning, memory and reasoning.

Turmeric (95% curcuminoids)is a spice that has been used for thousands of years in Indian medicine. Growing evidence suggests that oxidative stress, free radicals and beta amyloid in Alzheimers are caused by factors such as metal toxicity and abnormal inflammatory reactions. Curcumin has been extensively researched in patients with Alzheimer’s (Mishra and Palanivelu, 2008). Particular interest has been taken into the epigenetic effects of curcuminoids. Experiments using animal models have also been conducted to ascertain the effects of curcumin on impaired cognition and neuronal plasticity induced by chronic stress (Xu, Lin, et al. 2009).

Lutein- A carotenoid which has been the focus of much evaluation into its effects on cognition when taken in conjunction with DHA (Johnson and McDonald, 2008).

Vitamin E contributes to the protection of cells from oxidative stress that causes free radical damage. Vitamin E protects lipid cell membranes from oxidative damage that is particularly important in the brain, as 60% of the brain is fat. Vitamin E acts as a chain breaking antioxidant preventing lipid destruction. Deficiency of Vitamin E is serious, producing neurological symptoms including memory loss (Pham and Plakogiannis, 2005)(Takatsu and Owada, 2009).

For optimum effectivity Memorymax is recommended to be taken with Metabolics B Complex and Metabolics Omega 3 or Krill Oil.

Please note: The European Food Safety Authority is examining the potential for a link between the consumption of alpha lipoic acid, and the development of insulin autoimmune disease in individuals with certain genetic polymorphisms. Whilst the EFSA works to establish whether or not a link exists, anyone who thinks they could be at risk of insulin autoimmune disease should seek professional medical advice before purchasing this product