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KHK Formula (Pot Of 60 Capsules)

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£25.31

This is a formula containing Resveratrol, Vitamin C , N Acetyl Cysteine , Coenzyme Q10 and Zinc. The constituents have been carefully chosen to provide mitochondrial protection from intracellular stress from uric acid and inhibition of the KHK enzyme involved in fructose breakdown into uric acid which can create further intracellular stress and ultimately gout. Increased uric acid is also associated with increased insulin resistance and visceral fat gain KHK is an abbreviation of KetoHexoKinase, another name for Fructokinase. KHK initiates the pathway through which most dietary fructose is metabolized catalyzing the phosphorylation of fructose to fructose 1 phosphate and Uric acid https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713076/ KHK activity is predominantly present in the liver, kidney, and intestines Resveratrol found in red grape skins much research has been published recently about its involvement as a potential antiobesity compound . The mechanism of action of Resveratrol has been researched and is considered to be involved in a number of pathways: 1) Inhibition of adipogenesis http://www.nrjournal.com/article/S0271-5317(12)00141- 8/abstract (During early stage of adipogenesis resveratrol prevented the maturation of preadipocytes and at the same time inhibited the insulin signaling system ) 2) Upregulating SIRT 1 gene ( skinny gene ) http://www.nature.com/articles/srep38186 https://www.ncbi.nlm.nih.gov/pubmed/12939617 Upregulating the SIRT1 gene promotes fat mobilization from white adipocytes 3) Regulating epigenetic gene silencing ( of KHK) Decreases mTOR signaling ) https://www.ncbi.nlm.nih.gov/gene/23411 4) Inhibits glucose uptake https://www.ncbi.nlm.nih.gov/pubmed/25307508 5) Directly inhibits phoshofructokinase 1 which is critical for glycolysis and cellular glucose consumption https://www.ncbi.nlm.nih.gov/pubmed/23454376 6) Upregulates AMPKinase pathway https://www.ncbi.nlm.nih.gov/pubmed/17438283 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002264 7) Resveratrol and caloric restriction have overlapping effects on gene expression on multiple tissues http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002264 Vitamin C is a water soluble free radical scavenger and can regenerate vitamin E in cell membranes, so protecting them from further damage. Vitamin C has been shown in 13 randomised controlled trials to significantly reduce serum uric acid https://www.ncbi.nlm.nih.gov/pubmed/21671418 High uric acid upregulates KHK which increases Fructose breakdown into more uric acid so repeating the damaging cycle Vitamin C also protects the DNA, proteins and lipids from oxidative damage N Acetyl Cysteine crosses cell membranes is and intracellular antioxidant. It reduces extracellular cysteine to cysteine, stimulating glutathione synthesis promoting detoxification and acting directly on reactive oxidant radicals https://www.ncbi.nlm.nih.gov/pubmed/8412205 NAC has greater bioavailability intracellularly than glutathione and can prevent apoptosis caused by oxidative stress such as that caused by uric acid https://www.ncbi.nlm.nih.gov/pubmed/12613655 CoEnzyme Q10 protects against oxidative intracellular stress https://www.ncbi.nlm.nih.gov/pubmed/19753652 and is included as it is one of the most significant lipid antioxidant that prevents free radical generation and modification of proteins, lipids and DNA. Intracellular stress can be caused by high concentrations of uric acid and depletion of ATP by fructose metabolism Zinc- When fructose is broken down by KHK to Fructose 1 Phosphate and Uric acid , the increase of Fructose 1 phosphate leads to increased triglycerides and increased lipogenesis . Adequate zinc inhibits F-1-Phosphate so inhibiting the generation of increased triglycerides Coyle , P., Tichelman, E. M., & Pauw , R. T. (2003). Zinc inhibition of hepatic fructose metabolism in rats. Biological Trace Element Research, 92(41). doi:10.1385/BTER:92:1:41 It also protects the DNA, proteins and lipids from oxidative damage This combination formula is a multifaceted approach towards intracellular protection from oxidative stress protecting the cell against oxidative stress from uric acid , a breakdown product of fructose and purines . High uric acid can upregulate certain enzymes associated with fat storage

KHK Formula (Pot Of 60 Capsules)

KHK Formula Food Supplement 60 Capsules


Ingredients:

Polygonum Cuspidatum, Hydroxypropyl Methylcellulose (capsule), N.Acetyl Cysteine, Ascorbic Acid, Coenzyme Q10, Zinc Citrate.

Directions: Recommended dose 1 capsule twice per day with food*. Do not exceed this recommended dose. Consume within 3 months of opening.

Warning: If pregnant or breast feeding, consult your healthcare practitioner before using. This product should not be used as a substitute for a varied diet.

Storage: Store in a cool, dry place out of reach of children.                                                                       

 

*The stated recommended dose can be changed as directed by your healthcare practitioner.

 

Product information

Serving size: 1 capsule

Each capsule contains                          %NRV*

______________________________________________

Vitamin C   .............................................. 100 mg ......       125 %

Zinc………………………………………     15 mg ……        150%

Polygonum Cuspidatum ……………   150 mg    ……………† 

(25% Resveratrol)

N Acetyl Cysteine………………………   100 mg  ………… …† 

Coenzyme Q10 ………………………   100 mg  ………… ……† 

 

 

† Nutrient Reference Value (NRV*) not established


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