Shopping bag

KHK Formula (Pot Of 60 Capsules)

Share this product


This is a formula containing Resveratrol, Vitamin C , N Acetyl Cysteine , Coenzyme Q10 and Zinc. The constituents have been carefully chosen to provide mitochondrial protection from intracellular stress from uric acid and inhibition of the KHK enzyme involved in fructose breakdown into uric acid which can create further intracellular stress and ultimately gout. Increased uric acid is also associated with increased insulin resistance and visceral fat gain KHK is an abbreviation of KetoHexoKinase, another name for Fructokinase. KHK initiates the pathway through which most dietary fructose is metabolized catalyzing the phosphorylation of fructose to fructose 1 phosphate and Uric acid KHK activity is predominantly present in the liver, kidney, and intestines Resveratrol found in red grape skins much research has been published recently about its involvement as a potential antiobesity compound . The mechanism of action of Resveratrol has been researched and is considered to be involved in a number of pathways: 1) Inhibition of adipogenesis 8/abstract (During early stage of adipogenesis resveratrol prevented the maturation of preadipocytes and at the same time inhibited the insulin signaling system ) 2) Upregulating SIRT 1 gene ( skinny gene ) Upregulating the SIRT1 gene promotes fat mobilization from white adipocytes 3) Regulating epigenetic gene silencing ( of KHK) Decreases mTOR signaling ) 4) Inhibits glucose uptake 5) Directly inhibits phoshofructokinase 1 which is critical for glycolysis and cellular glucose consumption 6) Upregulates AMPKinase pathway 7) Resveratrol and caloric restriction have overlapping effects on gene expression on multiple tissues Vitamin C is a water soluble free radical scavenger and can regenerate vitamin E in cell membranes, so protecting them from further damage. Vitamin C has been shown in 13 randomised controlled trials to significantly reduce serum uric acid High uric acid upregulates KHK which increases Fructose breakdown into more uric acid so repeating the damaging cycle Vitamin C also protects the DNA, proteins and lipids from oxidative damage N Acetyl Cysteine crosses cell membranes is and intracellular antioxidant. It reduces extracellular cysteine to cysteine, stimulating glutathione synthesis promoting detoxification and acting directly on reactive oxidant radicals NAC has greater bioavailability intracellularly than glutathione and can prevent apoptosis caused by oxidative stress such as that caused by uric acid CoEnzyme Q10 protects against oxidative intracellular stress and is included as it is one of the most significant lipid antioxidant that prevents free radical generation and modification of proteins, lipids and DNA. Intracellular stress can be caused by high concentrations of uric acid and depletion of ATP by fructose metabolism Zinc- When fructose is broken down by KHK to Fructose 1 Phosphate and Uric acid , the increase of Fructose 1 phosphate leads to increased triglycerides and increased lipogenesis . Adequate zinc inhibits F-1-Phosphate so inhibiting the generation of increased triglycerides Coyle , P., Tichelman, E. M., & Pauw , R. T. (2003). Zinc inhibition of hepatic fructose metabolism in rats. Biological Trace Element Research, 92(41). doi:10.1385/BTER:92:1:41 It also protects the DNA, proteins and lipids from oxidative damage This combination formula is a multifaceted approach towards intracellular protection from oxidative stress protecting the cell against oxidative stress from uric acid , a breakdown product of fructose and purines . High uric acid can upregulate certain enzymes associated with fat storage

KHK Formula (Pot Of 60 Capsules)

KHK Formula Food Supplement 60 Capsules


Polygonum Cuspidatum, Hydroxypropyl Methylcellulose (capsule), N.Acetyl Cysteine, Ascorbic Acid, Coenzyme Q10, Zinc Citrate.

Directions: Recommended dose 1 capsule twice per day with food*. Do not exceed this recommended dose. Consume within 3 months of opening.

Warning: If pregnant or breast feeding, consult your healthcare practitioner before using. This product should not be used as a substitute for a varied diet.

Storage: Store in a cool, dry place out of reach of children.                                                                       


*The stated recommended dose can be changed as directed by your healthcare practitioner.


Product information

Serving size: 1 capsule

Each capsule contains                          %NRV*


Vitamin C   .............................................. 100 mg ......       125 %

Zinc………………………………………     15 mg ……        150%

Polygonum Cuspidatum ……………   150 mg    ……………† 

(25% Resveratrol)

N Acetyl Cysteine………………………   100 mg  ………… …† 

Coenzyme Q10 ………………………   100 mg  ………… ……† 



† Nutrient Reference Value (NRV*) not established

Write Your Own Review

You're reviewing: KHK Formula (Pot Of 60 Capsules)

How do you rate this product?*
  1 star 2 stars 3 stars 4 stars 5 stars
Speed of delivery

© Metabolics ltd, 2019. All rights reserved. Metabolics is a limited company registered in England and Wales 2844683. VAT registration number GB 249 9873 34.

Metabolics ltd is registered with the U.S Food and Drug Administration pursuant to the Federal Food Drug and Cosmetic Act, as amended by the Bioterrorism Act of 2002 and the FDA Food Safety Modernization Act. 

Payments Accepted Online By Safe online payment via SAGEPAY

Privacy Policy | FAQs