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KHK Formula (Pot Of 60 Capsules)


This is a formula containing Resveratrol, Vitamin C , N Acetyl Cysteine , Coenzyme Q10 and Zinc.

Full product description

This is a formula containing Resveratrol, Vitamin C, N Acetyl Cysteine, Coenzyme Q10 and Zinc. The constituents have been carefully chosen to provide mitochondrial protection from intracellular stress from uric acid and inhibition of the KHK enzyme involved in fructose breakdown into uric acid which can create further intracellular stress and ultimately gout. Increased uric acid is also associated with increased insulin resistance and visceral fat gain KHK is an abbreviation of KetoHexoKinase, another name for Fructokinase. KHK initiates the pathway through which most dietary fructose is metabolized catalyzing the phosphorylation of fructose to fructose 1 phosphate and Uric acid KHK activity is predominantly present in the liver, kidney, and intestines Resveratrol found in red grape skins much research has been published recently about its involvement as a potential antiobesity compound . The mechanism of action of Resveratrol has been researched and is considered to be involved in a number of pathways: 1) Inhibition of adipogenesis 8/abstract (During early stage of adipogenesis resveratrol prevented the maturation of preadipocytes and at the same time inhibited the insulin signaling system ) 2) Upregulating SIRT 1 gene ( skinny gene ) Upregulating the SIRT1 gene promotes fat mobilization from white adipocytes 3) Regulating epigenetic gene silencing ( of KHK) Decreases mTOR signaling ) 4) Inhibits glucose uptake 5) Directly inhibits phoshofructokinase 1 which is critical for glycolysis and cellular glucose consumption 6) Upregulates AMPKinase pathway 7) Resveratrol and caloric restriction have overlapping effects on gene expression on multiple tissues Vitamin C is a water soluble free radical scavenger and can regenerate vitamin E in cell membranes, so protecting them from further damage. Vitamin C has been shown in 13 randomised controlled trials to significantly reduce serum uric acid High uric acid upregulates KHK which increases Fructose breakdown into more uric acid so repeating the damaging cycle Vitamin C also protects the DNA, proteins and lipids from oxidative damage N Acetyl Cysteine crosses cell membranes is and intracellular antioxidant. It reduces extracellular cysteine to cysteine, stimulating glutathione synthesis promoting detoxification and acting directly on reactive oxidant radicals NAC has greater bioavailability intracellularly than glutathione and can prevent apoptosis caused by oxidative stress such as that caused by uric acid CoEnzyme Q10 protects against oxidative intracellular stress and is included as it is one of the most significant lipid antioxidant that prevents free radical generation and modification of proteins, lipids and DNA. Intracellular stress can be caused by high concentrations of uric acid and depletion of ATP by fructose metabolism Zinc- When fructose is broken down by KHK to Fructose 1 Phosphate and Uric acid , the increase of Fructose 1 phosphate leads to increased triglycerides and increased lipogenesis . Adequate zinc inhibits F-1-Phosphate so inhibiting the generation of increased triglycerides Coyle , P., Tichelman, E. M., & Pauw , R. T. (2003). Zinc inhibition of hepatic fructose metabolism in rats. Biological Trace Element Research, 92(41). doi:10.1385/BTER:92:1:41 It also protects the DNA, proteins and lipids from oxidative damage This combination formula is a multifaceted approach towards intracellular protection from oxidative stress protecting the cell against oxidative stress from uric acid , a breakdown product of fructose and purines . High uric acid can upregulate certain enzymes associated with fat storage


"I was recommended to take these tablets by my Kinesiologist. I think as I have only just started taking them it is too early to tell if they are helping me but I am very hopeful they will help as her advise has helped me a lot previously"
Trusted Customer | Posted 2 months ago | Read full review
"Too soon to give any useful feedback on health response."
Richard Bland | Posted 6 months ago | Read full review
Each capsule contains:
Vitamin C
100 mg
125 %
15 mg
Polygonum Cuspidatum
150 mg
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Polygonum Cuspidatum, Hydroxypropyl Methylcellulose (capsule), N.Acetyl Cysteine, Ascorbic Acid, Coenzyme Q10, Zinc Citrate.

No Gluten Containing IngredientsNo Gluten Containing Ingredients
No Nut Containing IngredientsNo Nut Containing Ingredients
Recommended dose 1 capsule twice per day with food. The stated recommended dose can be changed as directed by your healthcare practitioner. Do not exceed this recommended dose. Consume within 3 months of opening.
If pregnant or breast feeding, consult your healthcare practitioner before using. This product should not be used as a substitute for a varied diet.
Store in a cool, dry place out of reach of children.
Serving size: 1 capsule